I have had a very good experience with 1Blocker so far. Not quite ublock origin but close enough that I almost never notice a difference from my daily desktop use. There is another extension called Vinegar that strips out YouTube ads, but unfortunately it only works with Safari on iOS and not Firefox (even though both are using the same core engine) so I need to remember to bounce over to Safari when watching YouTube vids.
Vinegar works with Safari on macOS too. I love it, switches YouTube over to the native video player, strips all the recommendations and other crap and only plays the video