Launching unsigned apps is a problem, especially if an app bundle contains multiple binaries, since by default you need to approve exception for each of them separately.

I know that it's possible to script that since Homebrew handles it automatically, but if you just want to use a specific app outside of Homebrew, experience is definitely worse than on Linux/Windows.

There are a lot of annoying hurdles when allowing some types of application access. Needing to manually allow things in the security menu, allowing unrecognized developers, unsigned apps. Nothing insurmountable so far, but progressively more annoying for competent users to have control over their devices.