At least for SponsorBlock you can run iSponsorBlockTV[1] on another computer on the same network - in addition to skipping sponsored segments, it also mutes YouTube’s own ads and auto-skips them as soon as it can.
I've been using this for a while. It's certainly better than nothing, but there are limitations. Most notably for me, automatic muting doesn't work when HomePods are the default output[1]