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> I would really love to have someone summarize how we "oversaw" Japan and Germany as opposed to Afghanistan.

Imperial Japan and Nazi Germany, bad as they were, still had traditions associated with modern civilization. After the war, the infrastructure was devastated, but they had what economists refer to as "human capital"-- experienced engineers, miners, farmers, architects, people in all construction trades, etc. They had the knowledge and the desire to rebuild, and with the Marshall Plan, the money to do it.

The Taliban doesn't want to build/rebuild Afganistan. They want it to remain firmly in the 7th century, albeit with modern weapons. There is certainly human capital in Afganistan, but they face a real uphill battle.


The outrage machine need fuel!


Years ago, I listened to the G. Gordon Liddy radio show. The most hilarious incident was when he had the famous political humorist Mark Russell on his show. Russell was in-studio and said something like, "Hey, you sent me this keyboard". Liddy, totally straight, said that they wanted him to play some pieces (Russell sang and played as part of his act) and since their studio was the size of a broom closet, they had to find one that fit and they sent it to Russell to make sure it was good enough.

Then Russell says something like "You know what my first thought was at getting a piano from G. Gordon Liddy?". "It was, is one of the keys wired to a stick of dynamite?". Liddy roared with laughter.

(You had to see the right cartoons as young person to appreciate this one).


With the check held in escrow, it makes cheating harder.

The contractor knows that the money has been paid by the company and won't be withheld after the job is done.

The company knows that the contractor doesn't have the money until the job is done.


-Selling a business built over decades


"Nice channel lineup you have here, it would be a shame if something happened to it."


You can get a serology test to see if you have covid antibodies. It really defeats the purpose of the double-blind.


Answering my own question, this would be the first two volumes of William Manchester's "The Last Lion", a comprehensive biography of Winston Churchill.


The math doesn't look too good, at least in the US.

There are currently about 100,000 vaccinations a day in the US. Ignoring the vaccines that need two doses, vaccinating 300 million people at that rate will take 3,000 days = 100 months = 8.3 years. At 1 million vaccinations/day, we're still looking at 300 days = 10 months. Logistics is not my thing, but a tenfold increase in vaccations may be a little optimistic. Better than an infinite wait, though.

I got a robocall from my regular pharmacy the other day, telling me that they would be involved in distributing covid vaccines "soon".

So I am definitely going along with the main idea about acting as if everyone I know (or run into on the street) has tested positive.


When the adults take charge in a few weeks, things will go much faster. Six million New Yorkers got smallpox vaccinations in one month in 1947. There is no leadership now. https://www.insidehook.com/daily_brief/history/new-york-smal...


Yeah, I'm expecting it to step up significantly soon. I keep seeing people doing back of the envelope calculations to determine how long it will take to vaccinate everyone at the current rate, but it's pretty obvious that it's not going to just continue at the current rate.

It's a huge missed opportunity that we weren't better prepared from the get go, given we've had all year to get ready, but it will get better.


The great thing is that the next time this happens, a vaccine can be created equally quickly.


Maybe... depends on the virus. This won’t work for things like HIV or rapidly mutating viruses. It will probably work for any relative coronaviruses


Actually, Moderna is working on an hiv vaccine using similar tech. Sounds like they're pretty early on in testing though.


There are many working on HIV vaccines. The virus mutates so fast that all previous attempts have failed. I wish them luck, but I'm not confident that it is possible. Time will tell.


I don't think that's the issue. With any virus, your immune system grows countermeasures exponentially (memory t-cells, antibodies, protein complements) to stop it. These stick around after the virus is gone. It's an immune system "memory"

In another infection, your cells still get infected, but the infection is just stopped very quickly. HIV has inscription and reverse transcription enzymes in it, so it can actually glue its sequence into your DNA. It changes your DNA enough to replicate it, but not enough that your cells change their structure so your immune system can't recognize them as infected (and those changes can cause your immune system to fail over time: AIDS).

Even if your body is primed to deal with HIV infections, if the infection happens, it's already too late.

I'm not sure who antiviral drugs like PREP work, but you'd need something like that permanently in your system.


Yes but if they don't do phase 1/2 safety trials ahead of time we will still have the months-long regulatory wait.


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