Do you have any source for this? I can find some "it-might-be-bad" studies through a quick googling, but in general the idea seem to be that excess B12 is thought to be unproblematic ("it's just peed out").
Can confirm, overdosing on Vitamin B6 is bad. Lots of very scary symptoms.
I accidentally poisoned myself with B6 from Magnesium tablets over the course of a year: https://davids.town/vitamin-b6-overdose (my levels were 38x the healthy range).
tl;dr: Always check your Magnesium for what else the tablet includes. If it contains Pyridoxine hydrochloride (i.e. Vitamin B6) or another Pyridoxine compound, find one that doesn't. Since then, Swisse is the only brand I've found that consistently sells "pure" Magnesium tablets here in Australia.
I take 50mg a day in a bio-available form pyridoxal-5-phosphate. Consider this form instead.
I'm taking it because there is some genetic evidence that I would benefit from doing so. No neuropathies thus far but it's only been about a month and a half.
I wasn't even aware I was ingesting B6, I was just taking the tablets for the magnesium (it was one of the few with the full 440mg dose I was recommended).
Blood tests since then have shown that my B6 levels are fine with my usual diet, I don't take multivitamins or supplements anymore.
I don't know much about B6 beyond my own experiences with it, so all I can say is make sure you've discussed it with your GP, and be aware of the coasting effect if you do happen to develop any neuropathic symptoms: https://en.wikipedia.org/wiki/Megavitamin-B6_syndrome
I have to admit I am troubled by reading all this including that it has a half-life.. I did have the assumption that water soluble meant that excess was eliminated out the same day as is the case with some things. I had literally never heard of this toxicity issue till last night. One problem in general is that supplements don't really come in a "smaller size" unless I guess, you get powder form instead of capsules. I will have to review the genetic data I have again.
Genetic data is useful to know really, especially for people with MTHFR mutations as many pathways get affected.
Vitamin B6 accumulates in the blood - it has an exceptionally long half-life on the order of several weeks. It's not an occasional overdose you have to worry about the most, but also chronic accumulation at low doses (even not much above RDA levels, single digit milligrams) and your blood levels - apparently there's a large individual variation in its metabolism (https://doi.org/10.1016/j.phanu.2020.100188)
UK/EU upper safety limits are at 10-12mg per day. US UL of 200mg is way past due for an overhaul.
I personally got sick from a B complex with 40mg pyridoxine after just 4 months. Developed dysautonomia (not a canonical example, but still a kind of neuropathy - damage to autonomic nervous system). Had random tachycardia and high blood pressure flares from various triggers every week, took a while to figure out what was really causing it. Your typical non-neurologist GP wouldn't know anything because "it's water soluble" and the textbooks say neuropathy develops at 200mg+. All symptoms mostly resolved after a month once I threw away everything with pyridoxine. Wouldn't touch it again, always on a lookout for B6 in my multis and supplements now. P5P form is thought to be safer, but also got people sick - look around on facebook B6 groups for more anecdata.
No problem with B12 as far as I know. It's not a neurotoxin unlike B6.
Why does your software keep failing during development? Don't you have the knowledge to make it work?
It's the old, non-iterative everything-up-front method to rocket development that's weird. At least as a developer it seems obvious that a more hardware-rich approach with a high iteration rate will lead to a better outcome in the end, _especially_ when you're trying to push hard on the technological boundaries.
That's part of the innovation; don't just build a single reaaally expensive ship that has to be perfect. Instead, build a _ship factory_ and crank them out (relatively) cheaply and fast.
> More background: I arrived in North America at 17 w $2000, a backpack & a suitcase full of books. Paid my own way thru college. Dropped out of Stanford Eng/Phys grad school w $110k in college debt.
> We started Zip2 with ~$2k from me plus my overclocked home-built PC, ~$5k from my bro & ~$8k from Greg Kouri (such a good guy — he is greatly missed).
> My Dad provided 10% of a ~$200k angel funding round much later, but by then risk was reduced & round would’ve happened anyway.
As a general principle I don't credit that kind of statement by that kind of person. This is because every time I've looked into one of them in depth it was very misleading. That kind of rich person generally misunderstands the question and misses significant support.
Edit: For example, while he did work on a farm to pay for college that farm was owned by his Mom's cousin. Working for family is generally a significant advantage.
Edit2: Having a wealthy childhood has enduring benefits even if the money doesn't last. For example, it significantly increased his chance of having access to a computer at age 12, which probably had an enduring impact on his coding skills.
I'm not saying that means he didn't work hard and isn't smart. I am saying that it's telling he thinks that kind of thing didn't also contribute.
> I am saying that it's telling he thinks that kind of thing didn't also contribute.
I don't see why you think that this is what he thinks? It's certainly not what I think. What he is doing is answering persistent claims going too far the other way; that his success is only because of seed money from his father.
Or, as you say seemingly somewhat derogatory, "daddy". Their relationship wasn't always that great as far as I understand it, but I don't know the details.
Fair point, I shouldn't have said "seed money". I stand by my earlier statements that
1. If someone has wealthy family members this tends to benefit them, and they tend not to realize it.
2. Growing up wealthy didn't guarantee Musk's success, but it made it easier than it would have been if he grew up poorer. This happens in ways that are hard for someone like him to realize. For example, he might not realize that if he'd grown up worrying about money there's a significant chance his brain would have noticably changed in a way that made it harder for him to function.
There are many people who had the resources but didn't, not sure about millions. There are also many people who could have been as successful but didn't have the resources. That's why I said:
> His success isn't all due to luck, he has genuine skills. ... But his success isn't all due to skill, either.
> Musk's contributions can pretty much be summed up by "already had a lot of money" and "hired smart people".
He almost went bankrupt getting their first small rocket to space. He wasn't exactly poor at the time thanks to paypal, but he didn't have anything close to unlimited funds. He is a billionaire now because he succeeded, not the other way around.
> [..] which the founders were the actual people creating their first products from scratch.
> which in turn rested on him being from an already wealthy family.
https://twitter.com/elonmusk/status/1005593651219582977, "I arrived in North America at 17 w $2000, a backpack & a suitcase full of books. Paid my own way thru college. Dropped out of Stanford Eng/Phys grad school w $110k in college debt."
I didn't mean to say he wasn't involved at all, just that imho (which doesn't matter) most of these companies would be fine without him. He is a savvy business player, knows how to grab available resources as well as the spotlight. I don't see anyone heralding Bezos or a few other CEOs I could name to this level and he's quite a bit more successful.
Sidenote, all but a few of his twitter mentions of Shotwell are responses to mentions of her and it seems like he's injecting himself into the discussion.
For me personally I have noticed that exercising helps me by modulating my food cravings.
I'll get hungry of course, but in a way where I'm more happy just eating some reasonable amount of actual food instead of stuffing myself with a bag of crisps or worse.
This might also be psychological; it feels good after exercising so I feel more inclined to stay on the path.
The result, either way, is that while I know from experience that just changing my diet works to lose weight, it becomes a lot easier to keep it up when also exercising.
No, it would be like reading a post that says “anyone who doesn’t have antilock brakes can fuck off and rot at home” and my post would be one asking “is there a line where someone can not use ABS and still not fuck off and rot at home?” What if they wear a seatbelt? ABS isn’t the only thing someone can do to stay safe on the road!
Analogies in the covid context are always bad though. The real question is: for a disease that kills less than 2% of people who test positive for it, most of those being older or already at risk, and in a world with vastly diminished efficacy against continually improving variants (with apparently unknown mortality rates), when does the GP think that we should all not rot in our homes? I’m vaccinated, but apparently I may need a booster. I probably won’t get said booster because playing whack-a-mole with this disease doesn’t seem worth it to me given my risk profile. Do I need to rot at home or am I cool to not fuck off and die because I got the original shot. Am I no better than the other disease ridden pieces of shit who didn’t even get the first shot in GP’s eyes?
This rhetoric surrounding the vaccine is the real thing that needs to rot at home and die.
> they fired the people working on core parts of the browser (Servo)
Just to clarify, Servo was never a part of Firefox. Maybe that's not what you meant, but I've seen it confused with Gecko before which is the actual browser engine used by Firefox.
And as much as I am puzzled by some of the design choices lately - for the android version of Firefox especially - I think that it would be a loss in more ways than one to lose the last (?) real alternative to the Chromium-based family of browsers.
But Servo, to the best of my knowledge, was* an R&D project to develop an new experimental engine. The parts lifted into Firefox are now presumably maintained and developed as a part of Firefox proper.
Don't get me wrong, I was disappointed when i heard that the Servo team was laid off. We are probably missing out on new exciting things that could have come out of it. I just wanted to clarify that cutting Servo did not, as far as I know, mean that any current part of Firefox is now unmaintained or undeveloped.
* Servo is still alive and developed outside of Mozilla, I don't know if's doing well or not.
Do you have any source for this? I can find some "it-might-be-bad" studies through a quick googling, but in general the idea seem to be that excess B12 is thought to be unproblematic ("it's just peed out").