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If we're being clear, it's going to be a lot more than that.

Our comments here on HN are almost certainly going to live in fame/infamy forever. The twitter firehose is a pathway to 140-character immortality essentially.

You can already summon an agent to ingest essentially an entire commenter's history, correlate it across different sites based on writing style or similar nicknames, and then chat with you as that persona, even more so with a finetune or lora. I can do that with my gmail and text message history and it becomes eerily similar to me.

History is going to be much more direct and personal in the future. We can also do this with historical figures with voluminous personal correspondence, that's possible now.

It's very interesting because I think the era before mass LLM usage but also after digitalization is going to be the most intensely studied. We've lived through a thing that is going to be on the cusp of history, for better or worse.


Hepatitis C has effectively been cured. Obesity, sickle cell, and cystic fibrosis have all heard their death knell though not a complete cure.

Hep C regimens are getting closer and closer to "take a pill for a couple months" - no more interferon injections or multiple rounds of multiple drugs.

Trikafta is a functional cure for 90% of CF patients, I believe - not easy or cheap but normalizes what you care about bar the administration of the treatment itself.

Sickle cell has CRISPR treatments that are incredibly invasive and awful but do functionally cure the disease more or less permanently for a cool "couple million"

And everyone knows about GLP-1 drugs for obesity. The latest batch are as good or better than bariatric surgery without, you know, the surgery part.


Great list!

There's also Leber congenital amaurosis, a form of blindness that now has a (very expensive) gene therapy: https://www.wgbh.org/news/2017-10-12/fda-panel-endorses-gene...


Triplebyte was a thing for a little while, maybe it's time for it to live again.

We took a trip to Alaska via RV, and were parked at a roadside. I got up at 11:30pm at "night" (broad daylight) to use the restroom and was so annoyed by the seagulls I went outside to yell at them.

It was eagles fighting over a salmon. They genuinely do sound and act exactly like seagulls.


I love watching them interact. I ended up ditching a show in Alaska to sit in a grocery parking lot and watched eagles quarrel for almost two hours. They're great.

And here I assumed they sounded like red-tailed hawks!

To expand and agree: turnips, beets, hard whole grains, if their baby teeth aren't visibly worn by the time they fall out, it wasn't hard enough.

Jaw and face bone grows by stimulation. It's not just a dental thing - it's sleep apnea, sinus infections, facial structure, voice timbre, and attractiveness.

If it's enough, they won't even need their wisdom teeth pulled - having your wisdom teeth pulled is substantially a standard american diet issue, not a human genetic issue.


Thanks, and 100% agree. We have never had to pull a wisdom tooth either and carrots were always the go-to roadtrip snack growing up.

It's funny because I mildly disagree with your core premise (orthodontics are unnecessary), they should just be necessary as a disability accommodation, essentially. If we had 10-30% of the population in wheelchairs because we didn't let kids walk I would find the wheelchair industry odious as well.

Right, most of the orthodontics websites say 70% of people need them. I understand wanting to justify a total market size but if people actually believe that, it's getting out of hand.

I've had carrots (and fruit and hard snscks) since I don't remember when.

My teeth have been crooked since forever. So?


The x-clacks-overhead of LLMs, perhaps.

Usually these relatively low height kinds of top-tank systems lose water for the entire apartment building, because there's one pump to raise the water to the tank, which then passively provides the pressure (usually through pressure regulators at each floor if I remember right).

Larger buildings tend to have multiple independent systems


My hobby pastimes have been gradually describing an interesting arc, starting from essentially the oldest human passtimes and advancing forward through time. I really need to stop and revisit flintknapping though. Wild edibles are a bit of a dice roll, and manual firemaking is actually quite a workout. Weaving is almost infinite in depth, and has a particular attraction to programmers for its historical connections. Woodworking and pottery are big wins, for people who are technical but want to get out of their own head. To quote Gibson:

"If they think you're crude, go technical; if they think you're technical, go crude. I'm a very technical boy. So I decided to get as crude as possible."

You can get very technical indeed in some of humanity's oldest industries.


I donated $100 to my state's gubernatorial campaign as a part of my annual "make the world a better place" campaign, and was surprised to receive a call from an unknown number the following day. It was the Governor, thanking me for my donation personally, and wondering if there were any issues close to my heart that she could keep in mind. Note that this was from her personal cell phone (for whatever value of personal an executive politician actually has, but still), and she invited me to phone her if I had any issues that the state government could resolve.

That's a wildly low sum of money for a 5 minute personal call, let alone even a modest intervention.


This is my favorite example, from a long time ago. I wish I could record the "Read Aloud" output, it's absolute gibberish, sounds like the language in The Sims, and goes on indefinitely. Note that this is from a very old version of chatgpt.

https://chatgpt.com/share/fc175496-2d6e-4221-a3d8-1d82fa8496...


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