Just curious, but how do you know that you are a "holder of the slow gene"?

a) personal experience, also my mom carries it. b) I had my exome sequenced in 2018, and Promethease generated a report from it that showed slow metabolizer in cyp1a2

Probably though 23andMe and the CYP450 enzyme CYP1A2.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6212886/

Actually went through fullgenomes.com - they apparently don't offer exome sequencing any more but for under $1200 getting your genome sequenced is interesting.

If you ask anyone who works in genetics, though, they'll advise you never to do it. It can be bad news, but there's virtually no good news there.

It's useful to have as a resource that you can dip into; for instance to check a specific thing like "how fast do I metabolise caffeine (bad example as youc can get that from a SNV checking service like 23&Me. However, never ever EVER dump your whole genome into a program that will output every match for some potential condition. Now that's not for the reason you might immediately think ("Oh no look at all the bad stuff"), but rather because the databases that tools like this use are pretty chock full of junk where some researcher threw in a reference - along with a few thousand others - to say that their particular piece of research implicates this gene at this poistion with this variant. I've seen it with my own eyes, and a lot of it is very low quality. You therefore need highly curated databases where the genotype-phenotype associations are well-defined and thoroughly researched. You'll spend the rest of your life either trying to prove/disprove every potential false positive, or just worrying yourself needlessly. So, yeah, it's not a bad resource to have if you can be responsible with it.

Hmm, now I'm interested in seeing if an LLM could be finetuned to give an effective quality score on such a study.

I had mine run twice through 23andMe just to make sure they didn’t get something wrong. I tried to get my full genome once but the company screwed me over.

And I take exception to your “no good news”.

I discovered a gene polymorphism that led to the discovery the reason for my immune deficiency and mood disorder.

I found it gave me agency as well since I know that these genes are all risk genes and not fully determinant genes.

It's funny because your post in another thread is one of the reasons I brought it up here.

I would regard that as one of the exceptions in the "virtually no" caveat.

Nowadays whole genome sequencing can be done for $300-400 (for 30x WGS, with 100x around $1000?), it's been on my TODO list for a few years.

They didn't just have 3 interns. They decided to showcase just the work of 3 interns. Still funny that they all start with an A.

5 weeks of work at minimum wage is nowhere near $16,800...

"I mean, it's one banana, Michael. What could it cost? 10 dollars?"

Some people live in a bubble.

I fat fingered the 2... that was supposed to be 25...

Flip those numbers. That's a full year of minimum wage... 16,000 / 8 / 40.

You should still be able to edit your comment.

Binary Decision Diagrams were also the first thing that came into my mind while reading the article.

In this case it is pretty obvious what was meant, isn't it?

Where is the problem in putting pseudocode in a CS paper?

At least in my experience, pseudocode is often too ambiguous to be implemented correctly, missing crucial details or simply wrong.

With real code, those problems are less likely.

I don't understand your comment. What does the IDE Eclipse have to do with Eclipse Theia?

People don't understand that one project can have more than one product.

The same confusion exists between Visual Studio and Visual Studio Code.

Also, Eclipse Theia could be the name of the last version of the Eclipse Java IDE since they named every major release of their IDE until recently.

Maybe they should have gone with Theia by Eclipse, or just drop the Eclipse in the name altogether.