have you considered Replace X25519 with a post quantum cryptography key encapsulation mechanism like kyber or saber?

What do you think about https://app.sesame.com/

Good insight. Yes, I do remember at the time, purposely thinking I must lead with my age knowing instinctively that somehow that would help me and they would be more likely to pay attention.

Your gut bacteria is the prevention and the cure.

That's a hypothesis. If we knew that for certain, it would be really big news; and we could investigate to learn why, and then we could isolate the causative factors and perhaps find other ways of deploying them… If you know something the rest of us don't, prove it: show us the evidence, show us the specific hypotheses, describe a repeatable experiment, show us the results if such an experiment has been performed.

If you don't know something the rest of us don't, don't be so arrogant about your pet theories. Such arrogance costs lives.

You do realize they already are investigating, right? Even looking into MS and parkinson. ALZHEIMER’S DISEASE (AD) and AD DEMENTIA Umbrella review (systematic reviews of SRs): https://www.nature.com/articles/s44400-025-00048-6

Systematic review + meta-analysis (basal microbiota; AD): https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002... https://pmc.ncbi.nlm.nih.gov/articles/PMC11672027/

Replicated case-control + functional metagenomics (AD dementia): https://alz-journals.onlinelibrary.wiley.com/doi/full/10.100...

Large-cohort metagenomics (stage-specific / early pathology signals): https://pubmed.ncbi.nlm.nih.gov/40164697

Mendelian randomization (AD): https://pubmed.ncbi.nlm.nih.gov/38788075/ https://www.sciencedirect.com/science/article/pii/S227458072... https://pubmed.ncbi.nlm.nih.gov/40665707/ https://journals.sagepub.com/doi/10.1177/25424823261422629 https://www.medrxiv.org/content/10.1101/2025.08.20.25333769v...

Narrative / mechanisms (useful synthesis, not primary causal proof): https://www.sciencedirect.com/science/article/abs/pii/S15681...

MILD COGNITIVE IMPAIRMENT (MCI) / DEMENTIA (cognition-focused evidence) Systematic review (MCI or Alzheimer’s dementia; PRISMA, PROSPERO): https://www.mdpi.com/2035-8377/17/10/155 https://pubmed.ncbi.nlm.nih.gov/41149776/

Scoping review (MCI and AD gut microbiomes + interventions, through Feb 2023): https://pmc.ncbi.nlm.nih.gov/articles/PMC12825029/

Systematic review of microbiota-targeted interventions for cognition/dementia risk: https://www.sciencedirect.com/science/article/pii/S027153172...

RCT-focused systematic review/meta-analysis of probiotics for cognitive impairment risk/AD/MCI: https://pmc.ncbi.nlm.nih.gov/articles/PMC12645680/

FMT in dementia/MCI context (review of effects across neuro cohorts): https://www.sciencedirect.com/science/article/pii/S266635462...

MULTIPLE SCLEROSIS (MS) Microbiome signatures via global data integration / ML: https://pmc.ncbi.nlm.nih.gov/articles/PMC12383397/

Systematic review/meta-analysis of probiotics in MS (preclinical + clinical): https://journals.plos.org/plosone/article?id=10.1371/journal...

Systematic review + meta-analysis (antimicrobial exposure and MS risk; microbiome-disruption relevant): https://www.sciencedirect.com/science/article/abs/pii/S22110...

Mendelian randomization (gut microbiota causally linked to MS): https://pubmed.ncbi.nlm.nih.gov/39065244/ https://www.mdpi.com/2076-2607/12/7/1476

Broad MS gut dysbiosis and therapeutic modulation review: https://pmc.ncbi.nlm.nih.gov/articles/PMC12668904/

MS gut-brain-barrier and intestinal barrier review: https://www.frontiersin.org/journals/immunology/articles/10....

Example MS cohort biomarker/signature work: https://www.nature.com/articles/s41598-024-64369-x https://www.nature.com/articles/s41598-025-19998-1

PARKINSON’S DISEASE (PD) Multi-cohort metagenomic meta-analysis (Nat Commun, 2025): https://www.nature.com/articles/s41467-025-56829-3 https://pubmed.ncbi.nlm.nih.gov/40335465/

Large metagenomics cohort (Nat Commun, 2022): https://www.nature.com/articles/s41467-022-34667-x

Integrated multi-cohort gut metagenome (Movement Disorders, 2023): https://pubmed.ncbi.nlm.nih.gov/36691982/ https://movementdisorders.onlinelibrary.wiley.com/doi/10.100...

Metagenomic analysis (Movement Disorders, 2024): https://pubmed.ncbi.nlm.nih.gov/39192744/

PD causal-inference and MR discussion (review-type synthesis): https://pmc.ncbi.nlm.nih.gov/articles/PMC12512240/

MR study example (PD gut microbiota): https://journals.lww.com/md-journal/fulltext/2025/10310/caus...

> You do realize they already are investigating, right?

Yes. I also realise they have not reached the conclusion of this investigation. (Imagine this attitude towards a police investigation: "They're investigating Roger Rabbit, therefore he must have dunnit!")

He sent the letter in April 1979! He was only 3 months into the job.

Classic, have the new guy deal with the fan mail.

Note to self. Build time machine and fix this.

That's amazing!

Is any content generated by ai?

on the tech, just the floatiness code, I'm not frontend dev but I knew what I wanted. Content: personal quotes from various sources, usually voice notes, therapy sessions, journalling, attempting to write. I've used claude to help me check tone, consistency, etc and sometimes followed its suggestions but the content is my particular brand. I do use AI (claude/notebookLM) a lot to analyse stuff though

This is fantastic! I've been doing this manually for years. My main focus is always what does the research show about xyz supplement on gut bacteria.

I would love to get your feedback on what data to prioritize and how to make it easier to browse.

I've learned from my last sprint that this project can get overwhelming. So now I am making it my priority to build a community of people I can reach out to for feedback and direction. If supplements is your thing, I would greatly appreciate being able to chat with you from time to time (even if it just a quick email!)

I am at lilouartz@gmail.com

Hi, not into supplements, but really appreciating your approach to building a community and the reasoning behind it (and that you're being so transparent about it!). I'll give this a go too, thanks for the inspiration :).

Removal worked well but it always downloads a white background no matter if I chose transparent

Thank you for the feedback. I will review the export logic and alpha channel handling to identify the cause. I appreciate you pointing this out.