Can you elaborate? What makes it a "huge dependency to maintain"? Is there anything that the Twisted project can do to make it easier? If this is actually a problem I'd really like to hear from users on the Twisted mailing list and bug tracker.
Twisted is a general purpose library/framework with lots of features. This is the "huge" part. In my previous projects I have used it a lot and appreciated it.
What I was trying to tell is if Scrapy uses only small part of library, it may be possible for developers to use similar constructs from Python's standard library. In any case dependency is dependency and it is always better to minimize code footprint.
