I can't overstate how common parts are for this. My motherboard wasn't officially on their list yet the only difficult I had was my USB keyboard windows/alt/ctrl key wouldn't properly work. I had to drop $50 on a Mac keyboard.
Was about on part with the difficulty of installing Ubuntu now-a-days.
They basically have blessed it as much as you could reasonably expect them to. With careful hardware selection you will have no issues. My only recommendation, in general, is to use a USB audio device rather than integrated audio.
I almost wish Apple would just quietly make this easier for folks, blessing it without explicitly blessing it.