As awesome as Lazarus appears to be here, Rebol is even more amazing in my opinion. There is no designer, but the GUI DSL is mind bending. Red is a Rebol inspired language that is also tiny with a compiler as well so you can build a nice cross-platform-native GUI and distribute it as a tiny executable (~1.5 MB). You can see the GUI stuff for both Rebol and Red. There's a YouTube video by Nick Antonnacio (spelling) that shows him building something like 40 GUI apps in an hour ranging from email apps to games like tic-tac-toe and snake...it was pretty crazy to see the first time.
Very cool, the examples that he builds are very similar to what I've built when I stated in Delphi (simple chats, word processors, music players) but to course Rebol is much more concise. I wish the controls would look more "native". Currently they look like Windows 3.11. Also... Downloading code over plain HTTP? Not good idea...
I'm checking out Lazarus currently.