For lots of brands, the core competency is marketing and every other aspect of the company is outsourced. E.g. Kylie Cosmetics which has 360M+/yr in revenue and uses Shopify.
I don't think this is true - I believe it's only their merchandise store that's on Shopify. Car purchases are done through their own, custom platform.
That said, there are definitely plenty of huge merchants running on Shopify turning over hundreds of millions of dollars through the platform - we work with quite a few of them.