I can only count a handful of sites that break with conventional blockers (uMatrix might be a different story) and those sites I can just avoid doing business with (only one I can remember recently is Patreon where the Facebook/Google ad scripts cause the entire page to be unusable).
That’s why I mentioned uMatrix specifically. It blocks everything but images and css loaded from other domains by default. Normal ad blockers don’t do that.
Funnily enough, Patreon works without a problem after allowing 2 CDNs and their usercontent domain.
uMatrix defaults to blocking nearly everything from third parties. Most sites do not work 100% properly; many 'simple' sites will not even render because of how common it is to outsource content delivery to cloudflare et al.
It's painful, but it's (for me) the only sane way to browse. I'm willing to trade a few seconds of determining what 3rd party sources I'm going to allow when visiting a new site in exchange for minimizing tracking and malicious ads.
