Sure we do. mRNA vaccines have been under development for over a decade now. And while none have been approved for human use yet, it's not for lack of safety data. There have been zero serious adverse events reported in the Moderna or Pfizer phase 1, 2, and 3 trials. The only side effects are mild fatigue, headache, and soreness that you would associate with an immune response. Furthermore there is no possible way that the vaccine can even cause long term effects; the mRNA breaks down naturally in the body almost immediately. Any side effects will be immediately present and related to acute immune response. Worrying about some vague long term "what if" problems that have no mechanism for action is just non-scientific magical thinking.
This is not how drug approval works. This will be distributed on a planetary scale. Even 0.001% of side effects can be a big issue at these scales. history actually has lots of evidence of "unquestionably safe" drugs, causing lots of pain eventually - read about Thalidomide, Aspirin and Reye syndrom etc. There is also chance of ADE, a very complex unpredictable phenomenon, which was present with the original SARS vaccines.
I think bringing up ADE is fear mongering at this point. In vaccines where we’ve seen ADE we usually see it in monkey trials and if not there, we see it in phase 3. SARS vaccines never made it to phase 3 because we kept seeing ADE early on and then it died out. To keep bringing it up at this point, when none of the hundred or so vaccines have seen it, seems a little ridiculous.
I agree, SARS-2 does not seem to produce ADE. However, it might be rare, but if it is there it is often fatal. On global scale this might be important.
>There is also chance of ADE, a very complex unpredictable phenomenon, which was present with the original SARS vaccines.
Again, apples and oranges. This is a completely different class of drugs compared to SARS vaccines from a decade ago. Those were based on live viruses, which the mRNA vaccines are not.
And? How can you make these kind of claims it has not been verified? Just because the mechanism is different it does not mean it is free from ADE. ADE is result of using improper antigen for creation of immune response. mRNA is not an antigen, the protein produced from it is. If you choose wrong antigen, and deliver it in any possible way, it will still create wrong immunity and will result in ADE.
