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[dupe] Pfizer creating booster targeting highly transmissible delta variant (cnbc.com)
13 points by quantumwoke on July 9, 2021 | hide | past | favorite | 13 comments



Hope they can just do a quick bridging study and have something released by mid-August.


Anyone knowledgeable on vaccines care to comment on how compatible a booster shot would likely be with other types of vaccine?

While the first 2 shots were relatively close together the problems of brand-matching seem simpler than they would be many months later.


I believe all vaccines, other than 3 Chinese ones with names starting with "Sino", target the spike protein and all indications I've seen have been that two doses of different protein-targeting vaccines work well together.

The bigger issue would be if "Original Antigenic Sin" [0] could impact the immune systems response, but that would be part of the testing prior to releasing the booster I'm sure.

[0] https://en.wikipedia.org/wiki/Original_antigenic_sin


> The bigger issue would be if "Original Antigenic Sin" [0] could impact the immune systems response

presumably if this is an issue at all - it'd be because most people are "locked into" the spike protein as the original antigen, as opposed to those naturally infected and therefore carrying a immune repetoire against however many 10+ other proteins in sars-cov-2.


https://twitter.com/josh_wingrove/status/1413306651625594894...

"The CDC and FDA have issued an unusual evening joint statement, which pushes back on Pfizer's announcement that it will seek approval for a third shot (second booster).

"Americans who have been fully vaccinated do not need a booster shot at this time,"

The news will continue to post stories and think pieces about new covid variants for several years knowing they'll get clicks.

This information whiplash from one set of experts and then another set of experts disagreeing with the first set, 24 hours later in the news cycle is gonna happen more and more.

Hopefully those that are vaccinated can move on with their lives, without boosters and without having to vaccinate their young children.


> Hopefully those that are vaccinated can move on with their lives

At least here in the Midwest, life is back to normal for all but the very most cautious. Even the people who were most glued to their televisions during the pandemic can't be made to care about "variants".

I really don't think it would be feasible at this point for the government to force restrictions back on people. I think the majority wouldn't comply.


>Hopefully those that are vaccinated

And the naturally immune/recovered - CDC estimates over 113 million in the US.


That's not equivalent unfortunately.

Vaccine-induced immunity has been shown to offer much broader protection than natural post-infection immunity, and reinfections are not rare with Delta.

Here's a recent study : https://twitter.com/OYCar/status/1412656966481039367?s=20


It looks like that study was done on < 300 people. Is that strong evidence?


That study, done in a lab and not in the real world, contradicts the latest real-world science on this issue. The two relevant studies:

1) A report in Nature that the natural immunity produced in people who have already had covid may last a lifetime. https://www.nature.com/articles/d41586-021-01442-9

2) The Cleveland Clinic--consistently regarded as one of the top hospital systems in the United States and in the world--recently shared a study of 52,238 patients showing zero incremental benefit from the jab to the previously infected, recommending that "people who’ve had COVID-19 don’t need to get vaccinated." https://www.healthline.com/health-news/new-study-determines-...


I thought the CDC advice was that those who are "naturally immune" should get vaccinated anyway for variant protection? That would seem to fit with this announcement at least.


Are you suggesting we can't move on unless the CDC says so?




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