That was my first concern. Cocaine is one of the oldest anesthetics, and still used in some limited circumstances. But there are a lot of derivative drugs, e.g novocaine that nearly ever dentist uses, which are basically cocaine without the dopamine high. Would this vaccine change novocaine's effectiveness in the patient?
It would be fairly easy to determine whether the antibodies bind to commonly used drugs that are derivatives of cocaine (this is basically what ELISA testing is for, and computer simulations would give you a general idea of whether it would bind or not). I would assume that this sort of testing would have been done prior to it being tested on humans, or at the very least would be done before it enters into common usage.
