I don't have one at home (they aren't that good for games so I haven't bothered to change my home setup) but just using it for the 8 hrs in the office a day was enough to get rid of the constant pain. Take a little getting used to , but really the way your hands sit on the keyboard make more sense than twisting them in to sit properly on a flat keyboard.
I have two of those keyboards, and I really like the layout. And it's one of the only keyboards that gives you a negative tilt angle. But I wish they were available with mechanical key switches. I have gone back to flat keyboards with cherry brown switches, because as good as the layout on the ergonomic board is, the key action is unbearable.
I love my Microsoft Natural Ergonomic Keyboard 4000. Microsoft discontinued the model for a while, replacing it with a smaller, crappy version that had half-sized function keys and non-standard cursor key layout. I actually bought some 4000 models on eBay to scrounge for replacement parts. <:) I'm glad Microsoft has apparently resurrected this model.
I don't have one at home (they aren't that good for games so I haven't bothered to change my home setup) but just using it for the 8 hrs in the office a day was enough to get rid of the constant pain. Take a little getting used to , but really the way your hands sit on the keyboard make more sense than twisting them in to sit properly on a flat keyboard.