It's Bilberry, not Berberine, I always confuse the two..
Here's the study.
I have no idea wether the mechanism is from a classical antioxidant/anti-inflammatory/senolytic/pro autophagic mechanism or if bilberry has a unique action mechanism.
The field is so underfunded I expect most regular protectors (e.g. Skq1) to have similar or greater effects but i can't be certain.