My main concern is that perhaps there is an "attention threshold" on fundamental breakthrough results in physics and mathematics, and that we're diminishing the chances of ever getting such results again because theorists don't have enough attention to spare. If you spend all day writing grant proposals and trivial papers (just for the sake of publishing), then go home and veg out on Netflix and Twitter, when are you supposed to have that quality "sitting and thinking" time?
That the society is moving away from the concept of calling or vocation is also a problem. As a scientist (or physician or nurse or whatever) you are no longer rewarded for devoting your life to such things. You will not be supported (maybe even shamed for your enthusiasm or for failing in the reas of life that you are sacrifying), noone will watch your back, the administration will blame you for what they can, and you will not be paid overtime of course
