None of the links concludes that interactions with groups above the size of the dunbar number are detremental. None of this says that large gatherings are "unnatural" and certainly does not provide arguments why we should not allow gatherings or interactions beyond a certain point of people involved. It states that there is a certain number we can actively and comfortably manage, but nothing about the quite wide reaching things you postulated.
A website operator who wants to publish pages managed and edited by 150 of his "friends" would be acceptable.
A website operator who wants to hand out pages to 100,000 people would not be acceptable.
https://journals.plos.org/plosone/article?id=10.1371/journal...
https://arxiv.org/abs/1105.5170
https://arxiv.org/abs/1011.1547
https://pdodds.w3.uvm.edu/teaching/courses/2014-01UVM-303/ou...
https://www.newyorker.com/science/maria-konnikova/social-med...