While making money is a big game, it's not the only game. Your thoughts and actions leads to behaviors off your computer. This is why we see all kinds of political spam and propaganda to affect your choice at the ballot box.
As long as we assume that the html web doesn't completely die and remains significantly larger, it will always remain the biggest target for those kind of activities. Better to have a potential target of millions, than a target of hundreds or thousands.
Depends what you're targeting. For example targeting a much smaller self select group of 'computer experts' for a watering hole attack of one type or another is a great way to get in to some juicy systems.
If a system is machine readable and writable (which AI is fastly increasing this definition) you must assume that not only can you be attacked, you must assume that you are being attacked.
While making money is a big game, it's not the only game. Your thoughts and actions leads to behaviors off your computer. This is why we see all kinds of political spam and propaganda to affect your choice at the ballot box.