Sure, but now your interaction with macOS is limited to automated testing and not compilation + testing. Depending on the application, this could be worthwhile.

For example, at work, we cross-compile C/C++/Fortran/Rust code in R packages. We compile for supported versions of R, so that ends up being tens of thousands of packages that we need to compile.

By cross-compiling we saved a lot of work and nearly eliminated our need for macOS.