Yes they’re synthetic. Pills take much longer than pouches since they have to go through the digestive system, whereas pouches steadily release nicotine that is absorbed quickly by the gums.

Method of consumption is definitely important. I couldn’t fully switch to vapes until I found one that had the same “throat feel” as my American Spirits. Not just the type of nicotine (salts) but the exact brand of vaporizer and coil style. Just like people prefer the taste and ritual of coffee to caffeine pills.