Spam? Easy. Someone selling something? Spam! I might set up an automatic email responder that reads an emails contents, runs it through my own LLM, and if the email is trying to sell me something, auto reply with “fuck off!”
I'd rather delete/block it than reply/react to it at all. If you react, they know you exist and you are a valid target to re-target repeatedly, resold to other marketers.
Sadly I think it is illegal to sing up these addresses to every service known to you... Otherwise it would be interesting SaaS opportunity. Automatically sing-up spammers to any number of newsletters or contact forms...
When they're paying real money to scam you, wasting their time isn't a terrible idea. Like keeping the Microsoft virus scammers on the phone for an hour while you set up a virtual machine for them to remote into.