Glucose and fructose will react non-specifically with proteins in the body, particularly when present in excess. These non-specific reactions are recognized as foreign and/or defective, which triggers inflammation. The apply named RAGE protein is one mediator of this response (https://en.wikipedia.org/wiki/RAGE_(receptor)).

HbA1C results from the non-enzymatic reaction between glucose and hemoglobin. It serves as a measure of your long-term glucose level and is elevated in diabetics.

Low carb diets dramatically reduce this source of inflammation.