With these games your macro strategy is a lot more important than doing any kind of hair trigger reaction. Like your 3rd move in a 5 move sequence might come with iframes or a gap creator, so you need to keep track of where you are in the moveset and try to time it with the boss's actions. However, you are never asked for highly precise inputs.

The game is built to be played on a screen with your fingers blocking some elements after all.