The bane of most gene therapy research is lack of persistence. With how serious and morbid HD is, I’d guess patients will take their chances.

if I understand correctly it only injects a "gene cassette" which forms an episome (a plasmid-like thing, ie. just a ring of DNA outside the nucleus, just floating around in the cell), so it's non-integrating

https://youtu.be/q8HIubDJiMI?t=41

Mentioning that might have just been Guardrails…