Very cool. Surprising that having more AMPA receptors would lead to decreased cognition, as learning & memory is hypothesized to particularly involve processes that increase the number of in-position AMPA receptors.
> Surprising that having more AMPA receptors would lead to decreased cognition
The study only looked at one marker. It doesn't confirm that increased AMPA receptor density is the cause of decreased cognition. It only suggests that decreased cognition is correlated with increased AMPA receptor density.
There are many processes in the body where reduced activation of a receptor system results in an increased number of those receptors. So don't conclude that this is the reason why patients have brain fog. I would guess it's just more of a symptom than a cause until there's more research
In biology, cause and effect do not work the way they work in other fields. Effect is highly context-specific and things often work in the opposite direction than you might assume.
