Human relationships are part of most families, most work, etc. Could get tedious constantly dealing with people who lack any resilience or understanding of other perspectives.
The point is you wouldn't deal with people. Every interaction becomes a transaction mediated by an AI that's designed to make you happy. You would never genuinely come in contact with other perspectives; everything would be filtered and altered to fit your preconceptions.
It's like all those dystopias where you live in a simulation but your real body is wasting away in a vat or pod or cryochamber.