This is a great article. The linked article ("Anti-Authoritarians and Schizophrenia: Do Rebels Who Defy Treatment Do Better?") is also very interesting:
"At the 2-year assessment there were no significant differences in severity of psychosis between schizophrenic patients (SZ) on antipsychotic medications and SZ not on any medications. However, starting at the 4.5-year follow-ups and continuing over the next 15 years, the SZ who were not on antipsychotic medications were significantly less psychotic than those on antipsychotics.”
Sounds like persons who are less functional feel that they need medication more than those who don't. Not that anyone WANTS neuroleptics, the side effects sound terrible.
I would imagine that anyone who wants to deal through them is going to necessarily have more troubles.
This is covered quite thoroughly in chapter 6 of Whitaker's Anatomy of an Epidemic, which has extensive citations of the history and research on this problem.
Neuroleptics make schizophrenia patients more biologically vulnerable to psychosis. Standard antipsychotics block 70-90% of D2 receptors in the brain. To compensate, postsynaptic neurons increase the density of their D2 receptors by 30% or more. The brain is then supersensitive to dopamine. This leads to dyskinetic and psychotic symptoms.
"At the 2-year assessment there were no significant differences in severity of psychosis between schizophrenic patients (SZ) on antipsychotic medications and SZ not on any medications. However, starting at the 4.5-year follow-ups and continuing over the next 15 years, the SZ who were not on antipsychotic medications were significantly less psychotic than those on antipsychotics.”