I use HD280's for guitar practice from my POD. They work really well in this case: as they're very analytical, and they don't leak. The closed cup helps me focus on listening to my playing v. the drums/bass.
However, they're really hard on most music that hasn't been mastered well. And that is pretty much all modern music.
That's what I'm wearing right now. Since I almost entirely away from horrifically mismastered stuff, it works out OK. Bass may not be the strongest but I'm not personally a big bass person. They're definitely monitor-style headphones meant for accuracy rather than "bass-boosting". If you're looking for a closed headphone set with that as the goal, it's a decent buy as they seem to run ~$80, given how many people are tossing around multi-hundred dollar recommendations.
It really does seal you off from your environment a bit... I can't hear my cell phone ring in my pocket when I have them on.
However, they're really hard on most music that hasn't been mastered well. And that is pretty much all modern music.