The connection to HN, IMHO, is this: Louis CK is extraordinarily creative and committed to his art and craft, attributes demanded of entrepreneurs. He sometimes figuratively "hacks" viewer's brains with clever, surprising, insightful works, even when he gets parts wrong. It's the kind of accomplishment I think we can aspire to. We want our code, or our hardware, or our bare idea, to change minds, to inspire discussion, and even to disrupt lazy convention.

Oh, and the topic of this episode is not at all removed from women in tech, and how to "get it" and treat people well, regardless of age, size, shape, gender, religion, etc; these are perennial HN topics, if I'm not mistaken.