Using words instead of punctuation isn't so bad --- I would be willing to learn a creole pidgin in exchange for being able to program without punctuation characters and using Voice Recognition. But three-word keywords like "is equal to" just make it impossible to intuit the AST from the language, and intuiting the AST is ultimately what makes a programmer feel comfortable with the languages. In this regard, AppleScript was like SQL but worse.

Python, OTOH, strikes a decent balance (assuming de-punctuating is your goal), avoiding punctuation by using keywords for 'and' and 'or' and 'not' , without making the grammar incomprehensible.