One question I always ask my interviewers is "What is the best thing about working here?". You can tell a lot by their immediate response and whether their face lights up with excitement. One answer I will never forget is a developer responding with "We have a Dyson hand dryer".
An equally interesting, and perhaps more useful, question I always follow that with is "What's the worst thing about workign here"... The cop out answer is usually 'it's a big company so you get some politics and inefficiencies'.. I suppose a good follow up would be; "how does the company intend to change this going forward?" or even "how does it compare to other places you've worked"
It depends on your priorities. Do you just need someone to come and fill a spot or would you prefer someone that's actually a good mutual fit for the role?