" synthetics I'd say no unless there was a means to produce a quantity and quality of LSD or X akin to seeing the alcohol content written on a bottle of beer."
Trivial for your modern pharmaceutical organization. Also, LSD in particular has a huge ratio between it's normal dose and it's LD-50 - I did a bit of searching, and I couldn't actually find a case of someone having overdosed to the point of dying of LSD, so it's unclear to me what the LD50 is - but it's big - having a 10x overdose of LSD isn't going to kill you.
This is unlike caffeine of course, where I've personally had friends hospitalized for caffeine overdose, and there are certainly records of people having died from too much caffeine. People have died from drinking too much water as well.
Anyways, the entire idea behind legalization of things like LSD, THC, MDMA, Heroin, etc... is that you normalize the dosage, and reduce the number of fatalities resulting from poor quality control.
> having a 10x overdose of LSD isn't going to kill you
Toxicity is meaningless in the face of losing your mind; you may not physically die in the above scenario, but rest assured you will be absolutely out of your fucking tree for quite some time, if not hospitalized.
Compare that to eating too many ganja brownies, drinking too much alcohol, etc. Yes, you could die, but if you don't you'll be out of sorts for a couple of days and then more or less back to normal.
Too much alcohol certain can, and frequently does, kill people.
Doing 10x overdose of MDMA has a not insignificant chance of killing you.
Doing 10x overdose of Heroin will likely kill you.
Never having tried LSD, I can't comment on what the psychological effects of 10 hits of LSD will be, but given that Erowid suggests starting with a dosage of 25 ug, and that the optimal dosage is between 50 and 200 ug, it's not clear to me that 250 ug (a 10x over the base dose) will really be that big a deal (beyond how big a deal LSD normally is). Perhaps you are referring to 10x of your optimal dose (i.e. if normally you take 200 ug, suddenly taking 2000 ug)
Regardless, I think it's a bit of a stretch to suggest that, "Toxicity is meaningless in the face of losing your mind" - I had some pot brownies once, and went to a very twisted universe. At the time it was pretty scary for the better part of an hour, I just curled up into a tiny ball, but I look back fondly on the experience.
I don't know anybody who has ever done drugs, and thought that "toxicity is meaningless in the face of losing your mind." Some people do drug just to lose their mind.
Hmmm, I may have misunderstood what the OP meant by 10X overdose. If he meant "just" 10 hits of typical street acid (75ug) for most that would be way, way too much, but far from what I was understanding (overdose to me equating to something like 1,000ug, an amount very few would ever take).
re: losing your mind, sure, THC can trigger all manner of darkness, have been on my knees a couple of times praying to get me through it -- hallucinogens can bring the good and the bad ;-)
re: people doing drugs to lose their mind, right, keep in mind the context (10X overdose = 10,000ug). There's losing your mind, and then there's lost your mind.
Trivial for your modern pharmaceutical organization. Also, LSD in particular has a huge ratio between it's normal dose and it's LD-50 - I did a bit of searching, and I couldn't actually find a case of someone having overdosed to the point of dying of LSD, so it's unclear to me what the LD50 is - but it's big - having a 10x overdose of LSD isn't going to kill you.
This is unlike caffeine of course, where I've personally had friends hospitalized for caffeine overdose, and there are certainly records of people having died from too much caffeine. People have died from drinking too much water as well.
Anyways, the entire idea behind legalization of things like LSD, THC, MDMA, Heroin, etc... is that you normalize the dosage, and reduce the number of fatalities resulting from poor quality control.